{"id":59495,"date":"2018-01-01T12:21:48","date_gmt":"2018-01-01T12:21:48","guid":{"rendered":"https:\/\/leitat.org\/blog\/comboepoc\/"},"modified":"2025-02-24T20:35:43","modified_gmt":"2025-02-24T20:35:43","slug":"comboepoc","status":"publish","type":"post","link":"https:\/\/leitat.org\/en\/blog\/comboepoc\/","title":{"rendered":"COMBOEPOC"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"59495\" class=\"elementor elementor-59495 elementor-13654\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3102b130 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3102b130\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1ad6c67f\" data-id=\"1ad6c67f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5a45948b elementor-widget elementor-widget-heading\" data-id=\"5a45948b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">COMBOEPOC<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e71b65f elementor-widget elementor-widget-text-editor\" data-id=\"7e71b65f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5><span class=\"tlid-translation translation\"><span class=\"\" title=\"\">Exploration and Proof of Concept of the efficacy of combined treatment with ORY-1001 in oncological indications<\/span><\/span><\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1632e1c0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1632e1c0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-545ac7e4\" data-id=\"545ac7e4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-52b9117d elementor-widget elementor-widget-text-editor\" data-id=\"52b9117d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: justify;\"><strong>ABSTRACT<\/strong><\/p><div class=\"text-wrap tlid-copy-target\"><div class=\"result-shield-container tlid-copy-target\" style=\"text-align: justify;\"><span class=\"tlid-translation translation\">The treatment of cancer, and especially in the more aggressive types, consists of combinations of drugs with different mechanisms of action in order to get rid of all cancer cells. The main problem with these therapies is that after lots of months or years of treatment, most patients end up becoming resistant and refractory to therapy. Therefore, the development of new therapies is important and, especially, the development of new combination therapies based on different mechanisms of action and acting on different cellular targets, and that aim to reduce the appearance of resistance phenomena.<\/span><\/div><div class=\"result-shield-container tlid-copy-target\" style=\"text-align: justify;\"><span class=\"tlid-translation translation\"><br \/>For all these reasons, the general objectives pursued by this project are four:<\/span><\/div><ul style=\"text-align: justify;\"><li class=\"result-shield-container tlid-copy-target\"><span class=\"tlid-translation translation\">To demonstrate the safety and efficacy of the combined treatment of ORY-1001 with SOC treatments in a clinical setting, by conducting two Phase IIa trials of the Concept Test in patients with AML and SCLC.<\/span><\/li><li class=\"result-shield-container tlid-copy-target\"><span class=\"tlid-translation translation\">To improve the in vitro and in vivo models that allow to optimize in the same experimental model the evaluation of drugs with diverse mechanisms of action and directed to the treatment of cancer, and to explore in them new possible synergistic combinations with the ORY- 1001.<\/span><\/li><li class=\"result-shield-container tlid-copy-target\"><span class=\"tlid-translation translation\">To validate the use of two preselected biomarkers for the stratification of SCLC patients as predictive markers of response to ORY-1001.<\/span><\/li><li class=\"result-shield-container tlid-copy-target\"><span class=\"tlid-translation translation\"> To identify and characterize new pharmacodynamic biomarkers useful for the stratification and \/ or monitorization of patients, predictors of the progression of the pathology and \/ or response to treatment, etc.<\/span><\/li><\/ul><div class=\"result-shield-container tlid-copy-target\" style=\"text-align: justify;\"><span class=\"tlid-translation translation\">The project aims to address this challenge through a strategy of personalized medicine and develop a battery of biomarkers for the correct stratification and monitoring of patients most likely to benefit from such treatment. It will also be necessary to develop new experimental models that allow the evaluation of this approach. <\/span><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-27622b27 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"27622b27\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-20a6552a\" data-id=\"20a6552a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-243572ee elementor-widget elementor-widget-text-editor\" data-id=\"243572ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Project Budget: <\/strong>1.500.458,20 \u20ac<strong><br \/><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17bafc77 elementor-widget elementor-widget-text-editor\" data-id=\"17bafc77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>LEITAT Budget: <\/strong>171.681,20 \u20ac<strong><br \/><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-71a3ff72\" data-id=\"71a3ff72\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-58fb573d elementor-widget elementor-widget-text-editor\" data-id=\"58fb573d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Financial Framework: <\/strong>RTC<strong><br \/><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3043e14b elementor-widget elementor-widget-text-editor\" data-id=\"3043e14b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contract number:\u00a0<\/strong>RTC-2017-6407-1<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-19abbb93\" data-id=\"19abbb93\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4d86282d elementor-widget elementor-widget-text-editor\" data-id=\"4d86282d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Start Date:<\/strong> 01\/01\/2018<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-237a0829 elementor-widget elementor-widget-text-editor\" data-id=\"237a0829\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>End Date:<\/strong> 31\/12\/2020<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1d3af549 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1d3af549\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-245e214\" data-id=\"245e214\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6ae0a98 elementor-widget elementor-widget-text-editor\" data-id=\"6ae0a98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Partners:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6952daa5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6952daa5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3ca9fd91\" data-id=\"3ca9fd91\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-251027e elementor-widget elementor-widget-image-gallery\" data-id=\"251027e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-1' class='gallery galleryid-59495 gallery-columns-4 gallery-size-full'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img fetchpriority=\"high\" width=\"600\" height=\"300\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/oryzon-1.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-1-50899\" decoding=\"async\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/oryzon-1.jpg 600w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/oryzon-1-300x150.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-50899'>\n\t\t\t\tCoordinator\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img width=\"313\" height=\"182\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/vhio.png\" class=\"attachment-full size-full\" alt=\"\" decoding=\"async\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/vhio.png 313w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/vhio-300x174.png 300w\" sizes=\"(max-width: 313px) 100vw, 313px\" \/>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img width=\"876\" height=\"438\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/iislfe.png\" class=\"attachment-full size-full\" alt=\"\" decoding=\"async\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/iislfe.png 876w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/iislfe-300x150.png 300w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/iislfe-768x384.png 768w\" sizes=\"(max-width: 876px) 100vw, 876px\" \/>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img loading=\"lazy\" width=\"200\" height=\"76\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2017\/08\/Leitat_ppt-200.png\" class=\"attachment-full size-full\" alt=\"\" decoding=\"async\" \/>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-55853f88 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"55853f88\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-71085de7\" data-id=\"71085de7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4b928648 elementor-widget elementor-widget-text-editor\" data-id=\"4b928648\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contact Manager:<\/strong> <a href=\"mailto:snieva@leitat.org\">S. Nieva<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b0e6902 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b0e6902\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-60c8d477\" data-id=\"60c8d477\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-272bedeb elementor-widget elementor-widget-image\" data-id=\"272bedeb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"155\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-1024x199.jpg\" class=\"attachment-large size-large wp-image-51091\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-1024x199.jpg 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-300x58.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-768x149.jpg 768w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-1536x298.jpg 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-de5311a elementor-widget elementor-widget-image\" data-id=\"de5311a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"535\" height=\"142\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2017\/07\/LOGO_FEDER_es-670x300-1.png\" class=\"attachment-large size-large wp-image-55475\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2017\/07\/LOGO_FEDER_es-670x300-1.png 535w, https:\/\/leitat.org\/wp-content\/uploads\/2017\/07\/LOGO_FEDER_es-670x300-1-300x80.png 300w\" sizes=\"(max-width: 535px) 100vw, 535px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-51ed9838\" data-id=\"51ed9838\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-42d38213 elementor-widget elementor-widget-text-editor\" data-id=\"42d38213\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Financiado por: FEDER\/Ministerio de Ciencia,Innovaci\u00f3n y Universidades \u2013 Agencia Estatal de Investigaci\u00f3n\/_Proyecto RTC-2017-6407-1<\/p><p>Objetivo Tem\u00e1tico del Programa Operativo: Promover el desarrollo tecnol\u00f3gico, la innovaci\u00f3n y una investigaci\u00f3n de calidad.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>COMBOEPOC Exploration and Proof of Concept of the efficacy of combined treatment with ORY-1001 in oncological indications ABSTRACT The treatment of cancer, and especially in the more aggressive types, consists of combinations of drugs with different mechanisms of action in order to get rid of all cancer cells. The main problem with these therapies is [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":50903,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[142],"tags":[112],"class_list":["post-59495","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-technologies-en","tag-projects"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>COMBOEPOC - Leitat Technological Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"COMBOEPOC - Leitat Technological Center\" \/>\n<meta property=\"og:description\" content=\"COMBOEPOC Exploration and Proof of Concept of the efficacy of combined treatment with ORY-1001 in oncological indications ABSTRACT The treatment of cancer, and especially in the more aggressive types, consists of combinations of drugs with different mechanisms of action in order to get rid of all cancer cells. 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