{"id":59504,"date":"2018-01-01T11:17:54","date_gmt":"2018-01-01T11:17:54","guid":{"rendered":"https:\/\/leitat.org\/blog\/cals100\/"},"modified":"2025-02-24T20:35:35","modified_gmt":"2025-02-24T20:35:35","slug":"cals100","status":"publish","type":"post","link":"https:\/\/leitat.org\/en\/blog\/cals100\/","title":{"rendered":"CALS100"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"59504\" class=\"elementor elementor-59504 elementor-13683\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4b31c2c8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4b31c2c8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4fbdc643\" data-id=\"4fbdc643\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-48dce2f5 elementor-widget elementor-widget-heading\" data-id=\"48dce2f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">CALS100<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5317e61c elementor-widget elementor-widget-text-editor\" data-id=\"5317e61c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5>Automated analytical system based on fecal biomarkers for the diagnosis of intestinal inflammatory diseases<\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5f1487d1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5f1487d1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5adf9cea\" data-id=\"5adf9cea\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2a55bbe7 elementor-widget elementor-widget-text-editor\" data-id=\"2a55bbe7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>ABSTRACT<\/strong><\/p><p><span class=\"tlid-translation translation\">The main objective of the project is the development and validation of an automated clinical analysis system for the measurement of calcium-binding proteins calprotectin (S100A8 \/ S100A9), calgranulin C (S100A12) and stool protein S100A4, as a differential diagnostic test for intestinal inflammatory diseases, such as ulcerative colitis, Crohn&#8217;s disease or indeterminate colitis.<\/span><\/p><p><span class=\"tlid-translation translation\">The method will be based on immunoturbidimetric tests with monoclonal antibodies, and will be able to measure the concentration of the different analytes in faeces for diagnostic purposes and to monitor inflammatory intestinal pathologies. The reagents will be based on latex microparticles coated with specific monoclonal antibodies that, when reacting with the analytes present in the patient&#8217;s faeces, will agglutinate each other increasing the turbidity of the medium (which can be monitored by photometry).<\/span><\/p><p><span class=\"tlid-translation translation\">To develop the reagents, specific monoclonal antibodies will be generated for calprotectin (S100A8 \/ S100A9), calgranulin C (S100A12) and protein S100A4. To have the automated assays, the reagents will be adapted to the biochemical random access analyzers dedicated to Immunoturbidimetry. A metrological validation and a clinical study of the diagnostic capacity of the measurement procedures developed will be carried out, with the participation of patients affected by inflammatory bowel disease. Finally, and in order to also cover the diagnosis and the patient care, the multiplexed development of rapid qualitative tests of immunochromatography or lateral flow will be explored, without needing to go to the clinical laboratory for its determination.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-55a1bb6d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"55a1bb6d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-7273eada\" data-id=\"7273eada\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6353c285 elementor-widget elementor-widget-text-editor\" data-id=\"6353c285\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Project Budget: <\/strong>917.751,11 \u20ac<strong><br \/><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4e7cc54 elementor-widget elementor-widget-text-editor\" data-id=\"4e7cc54\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>LEITAT Budget: <\/strong>220.711,55 \u20ac<strong><br \/><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-775d6ca1\" data-id=\"775d6ca1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4bb692a1 elementor-widget elementor-widget-text-editor\" data-id=\"4bb692a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Financial Framework: <\/strong>RTC<strong><br \/><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-798d4a6c elementor-widget elementor-widget-text-editor\" data-id=\"798d4a6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contract number: <\/strong>RTC-2017-6564-1<strong><br \/><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-33b0245a\" data-id=\"33b0245a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-12a8fd57 elementor-widget elementor-widget-text-editor\" data-id=\"12a8fd57\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Start Date:<\/strong> 01\/01\/2018<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-104e4c14 elementor-widget elementor-widget-text-editor\" data-id=\"104e4c14\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>End Date:<\/strong> 31\/12\/2020<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-12589012 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"12589012\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-436878ec\" data-id=\"436878ec\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-46f08adf elementor-widget elementor-widget-text-editor\" data-id=\"46f08adf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Partners:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-306562 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"306562\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1c56c123\" data-id=\"1c56c123\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6c0cd40d elementor-widget elementor-widget-image-gallery\" data-id=\"6c0cd40d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-1' class='gallery galleryid-59504 gallery-columns-4 gallery-size-full'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img fetchpriority=\"high\" width=\"600\" height=\"124\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/biosystems.png\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-1-50911\" decoding=\"async\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/biosystems.png 600w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/biosystems-300x62.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-50911'>\n\t\t\t\tCoordinator\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img width=\"383\" height=\"131\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/idival-2.jpg\" class=\"attachment-full size-full\" alt=\"\" decoding=\"async\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/idival-2.jpg 383w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/01\/idival-2-300x103.jpg 300w\" sizes=\"(max-width: 383px) 100vw, 383px\" \/>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img width=\"200\" height=\"76\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2017\/08\/Leitat_ppt-200.png\" class=\"attachment-full size-full\" alt=\"\" decoding=\"async\" \/>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-437b69ec elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"437b69ec\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-100d52a\" data-id=\"100d52a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5b2b33a8 elementor-widget elementor-widget-text-editor\" data-id=\"5b2b33a8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contact Manager:<\/strong> <a href=\"mailto:iortiz@leitat.org\">I. Ort\u00edz<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-918619a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"918619a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-403b7ea5\" data-id=\"403b7ea5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6adf7951 elementor-widget elementor-widget-image\" data-id=\"6adf7951\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"155\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-1024x199.jpg\" class=\"attachment-large size-large wp-image-51091\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-1024x199.jpg 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-300x58.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-768x149.jpg 768w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-1536x298.jpg 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c88398 elementor-widget elementor-widget-image\" data-id=\"9c88398\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"535\" height=\"142\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2017\/07\/LOGO_FEDER_es-670x300-1.png\" class=\"attachment-large size-large wp-image-55475\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2017\/07\/LOGO_FEDER_es-670x300-1.png 535w, https:\/\/leitat.org\/wp-content\/uploads\/2017\/07\/LOGO_FEDER_es-670x300-1-300x80.png 300w\" sizes=\"(max-width: 535px) 100vw, 535px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-5b5b0d37\" data-id=\"5b5b0d37\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eaf84a1 elementor-widget elementor-widget-text-editor\" data-id=\"eaf84a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Financiado por: FEDER\/Ministerio de Ciencia,Innovaci\u00f3n y Universidades \u2013 Agencia Estatal de Investigaci\u00f3n\/_Proyecto RTC-2017-6564-1<\/p><p>Objetivo Tem\u00e1tico del Programa Operativo: Promover el desarrollo tecnol\u00f3gico, la innovaci\u00f3n y una investigaci\u00f3n de calidad.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>CALS100 Automated analytical system based on fecal biomarkers for the diagnosis of intestinal inflammatory diseases ABSTRACT The main objective of the project is the development and validation of an automated clinical analysis system for the measurement of calcium-binding proteins calprotectin (S100A8 \/ S100A9), calgranulin C (S100A12) and stool protein S100A4, as a differential diagnostic test [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":51103,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[142],"tags":[112],"class_list":["post-59504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-technologies-en","tag-projects"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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