{"id":59576,"date":"2017-10-01T09:54:58","date_gmt":"2017-10-01T09:54:58","guid":{"rendered":"https:\/\/leitat.org\/blog\/ntrack\/"},"modified":"2025-02-24T20:35:10","modified_gmt":"2025-02-24T20:35:10","slug":"ntrack","status":"publish","type":"post","link":"https:\/\/leitat.org\/en\/blog\/ntrack\/","title":{"rendered":"N-TRACK"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"59576\" class=\"elementor elementor-59576 elementor-10284\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-pntrvtg elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"pntrvtg\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eizetaq\" data-id=\"eizetaq\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-tsnbryq elementor-widget elementor-widget-heading\" data-id=\"tsnbryq\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">nTRACK<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-hvcqgip elementor-widget elementor-widget-text-editor\" data-id=\"hvcqgip\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5>Multimodal nanoparticles for structural and functional tracking of stem cell therapy on muscle regeneration<\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-jfmbfhg elementor-widget elementor-widget-text-editor\" data-id=\"jfmbfhg\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><a href=\"http:\/\/www.n-track.eu\" target=\"_blank\" rel=\"noopener\">www.n-track.eu<\/a><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-iarrkkx elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"iarrkkx\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-mdfpkgy\" data-id=\"mdfpkgy\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dnonidl elementor-widget elementor-widget-text-editor\" data-id=\"dnonidl\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: justify;\">Cell therapy offers promising opportunities to approach several diseases for which no effective therapies are currently available. However, the prognosis of the treatment efficacy commonly only relies on the progression of the disease symptoms. There is a need of tools to evaluate and predict the safety and success of cell-based treatments in earlier stages.<\/p><p style=\"text-align: justify;\">The current lack of methods providing real-time tracking of transplanted cells and knowledge on their early biodistribution and viability, is one of the major weakness of the available cell-based treatments.<\/p><p style=\"text-align: justify;\">The main goal of nTRACK is to develop a safe and highly sensitive multimodal nanoimaging agent enabling noninvasive, quantitative and longitudinal stem cell\u00a0 tracking and whole body biodistribution. nTRACK will also provide information on cell (long-term) viability using the combination of CT, MRI and PET, which are imaging modalities that are clinically available.<\/p><p style=\"text-align: justify;\">The synthesis of nTRACK NPs and cellular labeling processes will be scaled up and will follow goodJ manufacturing practice (GMP) requirements. A second goal is to establish a predictive model for early assessment of treatment effectiveness, based on short-term evaluation of the typical migration and biodistribution patterns of the stem cells. This predictive model could substantially improve overall management of the disease and will transform cell therapy treatment from \u201cone size fits all\u2019 concept towards personalised treatment.<\/p><p style=\"text-align: justify;\">The nTRACK technology will be demonstrated on a muscular injury sheep model, using imaging infrastructure commonly used in hospital settings. In addition, non-clinical safety studies on the nTRACK nanoparticles will be conducted following the conclusions of a series of formal interactions with regulatory authorities, to allow the prompt introduction into clinical trials after the end of the project.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-toalcka elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"toalcka\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-nmbuack\" data-id=\"nmbuack\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-wwnmjzx elementor-widget elementor-widget-text-editor\" data-id=\"wwnmjzx\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Project Budget:<\/strong> 6&#8217;863&#8217;865 \u20ac<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-xuqljbe elementor-widget elementor-widget-text-editor\" data-id=\"xuqljbe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>LEITAT Budget:<\/strong> 1&#8217;415&#8217;437 \u20ac<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-rstucjm\" data-id=\"rstucjm\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-khmgamx elementor-widget elementor-widget-text-editor\" data-id=\"khmgamx\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Financial Framework:<\/strong> Horizon 2020<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cmpkqkg elementor-widget elementor-widget-text-editor\" data-id=\"cmpkqkg\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contract number:<\/strong> 761031<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-zadiuai\" data-id=\"zadiuai\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-rpgmzuk elementor-widget elementor-widget-text-editor\" data-id=\"rpgmzuk\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Start Date:<\/strong> 01\/10\/2017<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-oyvfkdv elementor-widget elementor-widget-text-editor\" data-id=\"oyvfkdv\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>End Date:<\/strong> 30\/09\/2021<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-zzuiwbo elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"zzuiwbo\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-edkaexu\" data-id=\"edkaexu\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fofwibn elementor-widget elementor-widget-text-editor\" data-id=\"fofwibn\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Partners:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ifxkqpb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ifxkqpb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ityafjo\" data-id=\"ityafjo\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-jgjonfe elementor-widget elementor-widget-image-gallery\" data-id=\"jgjonfe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-1' class='gallery galleryid-59576 gallery-columns-4 gallery-size-excerpt-thumbnail'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img width=\"151\" height=\"57\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2017\/08\/Leitat_150_56.png\" class=\"attachment-excerpt-thumbnail size-excerpt-thumbnail\" alt=\"\" aria-describedby=\"gallery-1-47219\" decoding=\"async\" \/>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-47219'>\n\t\t\t\tCoordinator\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img width=\"169\" height=\"80\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2017\/08\/169x80xRijksinstituutP20voorP20volksgezondheid_0.jpg.pagespeed.ic_.Emd8t78dEb.jpg\" class=\"attachment-excerpt-thumbnail size-excerpt-thumbnail\" alt=\"\" decoding=\"async\" \/>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img fetchpriority=\"high\" width=\"681\" height=\"353\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2020\/05\/johannes-gutenberg-university-mainz-330-logo.png\" class=\"attachment-excerpt-thumbnail size-excerpt-thumbnail\" alt=\"\" aria-describedby=\"gallery-1-52115\" decoding=\"async\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2020\/05\/johannes-gutenberg-university-mainz-330-logo.png 681w, https:\/\/leitat.org\/wp-content\/uploads\/2020\/05\/johannes-gutenberg-university-mainz-330-logo-300x156.png 300w\" sizes=\"(max-width: 681px) 100vw, 681px\" \/>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-52115'>\n\t\t\t\tCoordinator\n\t\t\t\t<\/figcaption><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-kvmzpdx elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"kvmzpdx\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ifcyyau\" data-id=\"ifcyyau\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fkzsnlp elementor-widget elementor-widget-text-editor\" data-id=\"fkzsnlp\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contact Manager:<\/strong> <a href=\"mailto:rdesousa@leitat.org\">R. de Sousa<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bfvansh elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bfvansh\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-yzoyqwt\" data-id=\"yzoyqwt\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-rjpbyfn elementor-widget elementor-widget-image\" data-id=\"rjpbyfn\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"200\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2024\/12\/european-union-logo-300x200-1.png\" class=\"attachment-large size-large wp-image-55435\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-mooxcrh\" data-id=\"mooxcrh\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-kmiiktj elementor-widget elementor-widget-text-editor\" data-id=\"kmiiktj\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: justify;\">This project has received funding from the European Union\u2019s Horizon 2020 research and innovation programme under grant agreement No 760031. This publication reflects only the author\u2019s views and the European Union is not liable for any use that may be made of the information contained therein.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>nTRACK Multimodal nanoparticles for structural and functional tracking of stem cell therapy on muscle regeneration www.n-track.eu Cell therapy offers promising opportunities to approach several diseases for which no effective therapies are currently available. However, the prognosis of the treatment efficacy commonly only relies on the progression of the disease symptoms. There is a need of [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":49321,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[142,120],"tags":[112],"class_list":["post-59576","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-technologies-en","category-horizon-2020-en","tag-projects"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>N-TRACK - Leitat Technological Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"N-TRACK - Leitat Technological Center\" \/>\n<meta property=\"og:description\" content=\"nTRACK Multimodal nanoparticles for structural and functional tracking of stem cell therapy on muscle regeneration www.n-track.eu Cell therapy offers promising opportunities to approach several diseases for which no effective therapies are currently available. 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