{"id":75175,"date":"2024-07-31T10:42:54","date_gmt":"2024-07-31T10:42:54","guid":{"rendered":"https:\/\/leitat.org\/blog\/nextom\/"},"modified":"2025-12-18T08:03:54","modified_gmt":"2025-12-18T08:03:54","slug":"nextom","status":"publish","type":"post","link":"https:\/\/leitat.org\/en\/blog\/nextom\/","title":{"rendered":"NEXTOM"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"75175\" class=\"elementor elementor-75175 elementor-75161\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2cb2b84 e-flex e-con-boxed e-con e-parent\" data-id=\"2cb2b84\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-653a83e elementor-widget elementor-widget-text-editor\" data-id=\"653a83e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Development of Next-Generation ADCs (Antibody-Drug Conjugates) for the Treatment of Invasive Tumours<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f56ade0 e-flex e-con-boxed e-con e-parent\" data-id=\"f56ade0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7cb19e5 elementor-widget elementor-widget-text-editor\" data-id=\"7cb19e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Abstract:<\/strong><\/p><p>The <strong>NEXTOM<\/strong> project aims to <strong>develop innovative antibody-drug conjugates (ADCs) targeting components of the tumour microenvironment (such as FAP, Endoglin and Endo180), to treat invasive solid tumours with greater efficacy and lower toxicity<\/strong>.<\/p><p>The initiative includes the selection of therapeutic candidates, their validation in advanced preclinical models, including animals with a humanised immune system, and the study of their stability, pharmacokinetics, and toxicological profile. The manufacturing process and a pilot batch will also be developed to enable progress toward the clinical phase.<\/p><p><strong>Leitat&#8217;s role in the project:<\/strong><\/p><p>The project is led by <strong>Oncomatryx<\/strong>, with the collaboration of <strong>Leitat<\/strong>, which contributes its <strong>expertise in preclinical models, ADME, and bioanalysis<\/strong>.<\/p><p>NEXTOM seeks to expand the therapeutic arsenal available in oncology, strengthening innovation in stroma-targeted therapies and supporting the transition toward personalised medicine.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5423518 e-flex e-con-boxed e-con e-parent\" data-id=\"5423518\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7d48f8a e-con-full e-flex e-con e-child\" data-id=\"7d48f8a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-77e7b5e elementor-widget elementor-widget-text-editor\" data-id=\"77e7b5e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Project Budget<\/strong>: 2.437.053 \u20ac<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9ffc4f6 e-con-full e-flex e-con e-child\" data-id=\"9ffc4f6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-597e9dc elementor-widget elementor-widget-text-editor\" data-id=\"597e9dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Financial Framework<\/strong>: Proyectos de colaboraci\u00f3n p\u00fablico-privada 2023<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c888705 e-con-full e-flex e-con e-child\" data-id=\"c888705\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-887d019 elementor-widget elementor-widget-text-editor\" data-id=\"887d019\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Start Date<\/strong>: 01\/07\/2024<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2644b2e e-con-full e-flex e-con e-child\" data-id=\"2644b2e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3575974 elementor-widget elementor-widget-text-editor\" data-id=\"3575974\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Leitat Budget<\/strong>: 852.499 \u20ac<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-484fc54 e-con-full e-flex e-con e-child\" data-id=\"484fc54\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-08575d2 elementor-widget elementor-widget-text-editor\" data-id=\"08575d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contract Number<\/strong>: CPP2023-010413<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1fd440e e-con-full e-flex e-con e-child\" data-id=\"1fd440e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2e13c5a elementor-widget elementor-widget-text-editor\" data-id=\"2e13c5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"1174\" data-end=\"1392\"><strong>End Date<\/strong>: 30\/06\/2027<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6040881 e-flex e-con-boxed e-con e-parent\" data-id=\"6040881\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31433c4 elementor-widget elementor-widget-text-editor\" data-id=\"31433c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Partners:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ce7fee e-flex e-con-boxed e-con e-parent\" data-id=\"7ce7fee\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-29e5dec e-con-full e-flex e-con e-child\" data-id=\"29e5dec\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-af740db elementor-widget elementor-widget-image\" data-id=\"af740db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"202\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/OMTX_HD_sinfondo.webp\" class=\"attachment-large size-large wp-image-75167\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/OMTX_HD_sinfondo.webp 993w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/OMTX_HD_sinfondo-300x76.webp 300w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/OMTX_HD_sinfondo-768x194.webp 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1669e88 e-con-full e-flex e-con e-child\" data-id=\"1669e88\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-96901d7 elementor-widget elementor-widget-image\" data-id=\"96901d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"277\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-1024x355.png\" class=\"attachment-large size-large wp-image-69286\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-1024x355.png 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-300x104.png 300w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-768x266.png 768w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-1536x532.png 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1.png 2007w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8ef967b e-flex e-con-boxed e-con e-parent\" data-id=\"8ef967b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8d01860 elementor-widget elementor-widget-text-editor\" data-id=\"8d01860\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Project CPP2023-010413 funded by:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dfe8fa9 e-flex e-con-boxed e-con e-parent\" data-id=\"dfe8fa9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-44a45b6 elementor-widget elementor-widget-image\" data-id=\"44a45b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"155\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-1024x198.jpg\" class=\"attachment-large size-large wp-image-75298\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-1024x198.jpg 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-300x58.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-768x149.jpg 768w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-1536x298.jpg 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-2048x397.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Development of Next-Generation ADCs (Antibody-Drug Conjugates) for the Treatment of Invasive Tumours Abstract: The NEXTOM project aims to develop innovative antibody-drug conjugates (ADCs) targeting components of the tumour microenvironment (such as FAP, Endoglin and Endo180), to treat invasive solid tumours with greater efficacy and lower toxicity. The initiative includes the selection of therapeutic candidates, their [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":75163,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[149,142],"tags":[112],"class_list":["post-75175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aei-en","category-health-technologies-en","tag-projects"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NEXTOM - Leitat Technological Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NEXTOM - Leitat Technological Center\" \/>\n<meta property=\"og:description\" content=\"Development of Next-Generation ADCs (Antibody-Drug Conjugates) for the Treatment of Invasive Tumours Abstract: The NEXTOM project aims to develop innovative antibody-drug conjugates (ADCs) targeting components of the tumour microenvironment (such as FAP, Endoglin and Endo180), to treat invasive solid tumours with greater efficacy and lower toxicity. 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