{"id":75986,"date":"2026-01-12T11:19:59","date_gmt":"2026-01-12T11:19:59","guid":{"rendered":"https:\/\/leitat.org\/?p=75986"},"modified":"2026-01-12T11:33:47","modified_gmt":"2026-01-12T11:33:47","slug":"hpk1-inhib","status":"publish","type":"post","link":"https:\/\/leitat.org\/en\/blog\/hpk1-inhib\/","title":{"rendered":"HPK1-INHIB"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"75986\" class=\"elementor elementor-75986 elementor-75967\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-73935fd e-flex e-con-boxed e-con e-parent\" data-id=\"73935fd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d68ecbd elementor-widget elementor-widget-text-editor\" data-id=\"d68ecbd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Preclinical Discovery and Development of New Compounds as HPK1 Inhibitors for Cancer Treatment<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-06c088d e-flex e-con-boxed e-con e-parent\" data-id=\"06c088d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f182c8 elementor-widget elementor-widget-text-editor\" data-id=\"7f182c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Abstract:<\/strong><\/p><p data-start=\"176\" data-end=\"553\">The overall objective of the project is to discover and develop new HPK1 inhibitors at the preclinical level, with therapeutic potential in oncology. To achieve this, key stages will be addressed, including the design, synthesis, and optimization of compounds, evaluation of ADME properties, in vitro and in vivo efficacy studies, synthesis scale-up, and patent applications.<\/p><p data-start=\"555\" data-end=\"871\">The project will be carried out by a consortium composed of Medchemfarma, Leitat, and the University of Santiago de Compostela (USC), combining expertise in medicinal chemistry, pharmacology, and early drug discovery. Specialized service providers will also be subcontracted for specific stages of the development.<\/p><p data-start=\"873\" data-end=\"1160\">This project aligns with the objectives of the Recovery, Transformation, and Resilience Plan (PRTR), strengthening R&amp;D in health. A Technical Steering Committee will coordinate the work, ensuring the achievement of objectives, the protection of results, and their proper dissemination.<\/p><p data-start=\"873\" data-end=\"1160\">\u00a0<\/p><p><strong>Leitat&#8217;s role in the project:<\/strong><\/p><p>Leitat will act as a beneficiary partner in the HPK1-INHIB project.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-181444b e-flex e-con-boxed e-con e-parent\" data-id=\"181444b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-09b0ccd e-con-full e-flex e-con e-child\" data-id=\"09b0ccd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0eaab40 elementor-widget elementor-widget-text-editor\" data-id=\"0eaab40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Project budget:<\/strong> 896.221,99\u20ac<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8140e92 e-con-full e-flex e-con e-child\" data-id=\"8140e92\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-278b52e elementor-widget elementor-widget-text-editor\" data-id=\"278b52e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Financial framework:<\/strong> <span class=\"TextRun SCXW77155954 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW77155954 BCX8\">Proyectos de colaboraci\u00f3n p\u00fablico-privada 2022<\/span><\/span><span class=\"EOP SCXW77155954 BCX8\" data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2a682b4 e-con-full e-flex e-con e-child\" data-id=\"2a682b4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-15addf4 elementor-widget elementor-widget-text-editor\" data-id=\"15addf4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Start date: <\/strong>01\/03\/2023<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1f1b4f6 e-con-full e-flex e-con e-child\" data-id=\"1f1b4f6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1abfb99 elementor-widget elementor-widget-text-editor\" data-id=\"1abfb99\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Leitat&#8217;s budget:<\/strong> 200.396,63\u20ac<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d66261c e-con-full e-flex e-con e-child\" data-id=\"d66261c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1a2b3d0 elementor-widget elementor-widget-text-editor\" data-id=\"1a2b3d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contract number:<\/strong> <span class=\"TextRun SCXW80534510 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW80534510 BCX8\">CPP2022-009716<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ca06880 e-con-full e-flex e-con e-child\" data-id=\"ca06880\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ce05b25 elementor-widget elementor-widget-text-editor\" data-id=\"ce05b25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>End date:<\/strong> 28\/02\/2026<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d78e34b e-flex e-con-boxed e-con e-parent\" data-id=\"d78e34b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9fe5c91 elementor-widget elementor-widget-text-editor\" data-id=\"9fe5c91\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Partners:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2bd1ff2 e-flex e-con-boxed e-con e-parent\" data-id=\"2bd1ff2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-80e6797 elementor-widget elementor-widget-image\" data-id=\"80e6797\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"466\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/01\/partners-HPK1-INHIB-1024x597.png\" class=\"attachment-large size-large wp-image-75974\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/01\/partners-HPK1-INHIB-1024x597.png 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/01\/partners-HPK1-INHIB-300x175.png 300w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/01\/partners-HPK1-INHIB-768x448.png 768w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/01\/partners-HPK1-INHIB.png 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-673ac2d e-flex e-con-boxed e-con e-parent\" data-id=\"673ac2d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3b8d4cf elementor-widget elementor-widget-text-editor\" data-id=\"3b8d4cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Project CPP2022-009716 funded by:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d9f5997 e-flex e-con-boxed e-con e-parent\" data-id=\"d9f5997\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-16630cd elementor-widget elementor-widget-image\" data-id=\"16630cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"668\" height=\"156\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/08\/Imagen1.jpg\" class=\"attachment-large size-large wp-image-72541\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/08\/Imagen1.jpg 668w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/08\/Imagen1-300x70.jpg 300w\" sizes=\"(max-width: 668px) 100vw, 668px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Preclinical Discovery and Development of New Compounds as HPK1 Inhibitors for Cancer Treatment Abstract: The overall objective of the project is to discover and develop new HPK1 inhibitors at the preclinical level, with therapeutic potential in oncology. To achieve this, key stages will be addressed, including the design, synthesis, and optimization of compounds, evaluation of [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":75970,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[149,142],"tags":[112],"class_list":["post-75986","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aei-en","category-health-technologies-en","tag-projects"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HPK1-INHIB - Leitat Technological Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HPK1-INHIB - Leitat Technological Center\" \/>\n<meta property=\"og:description\" content=\"Preclinical Discovery and Development of New Compounds as HPK1 Inhibitors for Cancer Treatment Abstract: The overall objective of the project is to discover and develop new HPK1 inhibitors at the preclinical level, with therapeutic potential in oncology. 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