{"id":76161,"date":"2024-11-01T10:05:49","date_gmt":"2024-11-01T10:05:49","guid":{"rendered":"https:\/\/leitat.org\/blog\/meta-thrive\/"},"modified":"2026-01-13T10:22:56","modified_gmt":"2026-01-13T10:22:56","slug":"meta-thrive","status":"publish","type":"post","link":"https:\/\/leitat.org\/en\/blog\/meta-thrive\/","title":{"rendered":"META-THRIVE"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"76161\" class=\"elementor elementor-76161 elementor-76147\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-34ac27b e-flex e-con-boxed e-con e-parent\" data-id=\"34ac27b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5d036a8 elementor-widget elementor-widget-text-editor\" data-id=\"5d036a8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em><strong>Development of a new targeted therapy for the treatment of metabolically adapted tumors<\/strong><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1faf76d e-flex e-con-boxed e-con e-parent\" data-id=\"1faf76d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-20e1056 elementor-widget elementor-widget-text-editor\" data-id=\"20e1056\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Abstract:<\/strong><\/p><p>The main goal of this project is to <strong>develop a thymidine phosphorylase (TP) inhibitor as a completely novel oral, intracellular, and targeted therapy for cancer treatment<\/strong>. Beyond basic research, the focus is on advancing its pharmacological and preclinical development, aiming for superior efficacy and a favorable safety profile compared to current therapies.<\/p><p>The project includes several key objectives. First, efforts will focus on optimizing a TP inhibitor with good oral bioavailability through detailed analyses of pharmacokinetic properties and stability. In parallel, the antitumor efficacy of the candidate compound will be validated, both as a standalone treatment and in combination with other therapies, through in vitro and in vivo studies.<br \/>Another fundamental aspect of the project will be to better understand how TP inhibition impacts antitumor immune response, which could open the door to new combined therapeutic strategies. Finally, preclinical studies required by regulatory authorities will be conducted to prepare the necessary dossier for authorization to begin human trials.<\/p><p>With these advances, the project <strong>aims to<\/strong> <strong>position this inhibitor as an innovative oncology therapy, with the potential to significantly improve clinical outcomes and the quality of life of cancer patients<\/strong>.<\/p><p><strong>Leitat\u2019s Role in the Project:<\/strong><\/p><p>Leitat will act as a beneficiary partner in the META-THRIVE project.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e8b2a3b e-flex e-con-boxed e-con e-parent\" data-id=\"e8b2a3b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e508625 e-con-full e-flex e-con e-child\" data-id=\"e508625\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1e57ce5 elementor-widget elementor-widget-text-editor\" data-id=\"1e57ce5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Project&#8217;s Budget: <\/strong>1.347.532\u20ac<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fef62be e-con-full e-flex e-con e-child\" data-id=\"fef62be\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7be813e elementor-widget elementor-widget-text-editor\" data-id=\"7be813e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Financial Framework: <\/strong>Proyectos de colaboraci\u00f3n p\u00fablico-privada 2023<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3385525 e-con-full e-flex e-con e-child\" data-id=\"3385525\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-79f44d7 elementor-widget elementor-widget-text-editor\" data-id=\"79f44d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Start Date: <\/strong>01\/10\/2024<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6d198f4 e-con-full e-flex e-con e-child\" data-id=\"6d198f4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9df4087 elementor-widget elementor-widget-text-editor\" data-id=\"9df4087\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Leitat&#8217;s Budget: <\/strong>573.388\u20ac<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1c5f948 e-con-full e-flex e-con e-child\" data-id=\"1c5f948\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1c00e59 elementor-widget elementor-widget-text-editor\" data-id=\"1c00e59\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contract Number: <\/strong>CPP2023-010927<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e2a4ff2 e-con-full e-flex e-con e-child\" data-id=\"e2a4ff2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a061991 elementor-widget elementor-widget-text-editor\" data-id=\"a061991\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>End Date: <\/strong>30\/09\/2027<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0fbd8d1 e-flex e-con-boxed e-con e-parent\" data-id=\"0fbd8d1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-346d8b1 elementor-widget elementor-widget-text-editor\" data-id=\"346d8b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Partners:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-41a18fa e-flex e-con-boxed e-con e-parent\" data-id=\"41a18fa\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4a834d4 e-con-full e-flex e-con e-child\" data-id=\"4a834d4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-615551d elementor-widget elementor-widget-text-editor\" data-id=\"615551d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>COORDINATOR:<\/strong><\/p><p><img decoding=\"async\" class=\"wp-image-76152 aligncenter\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/01\/28799atg_therapeutics-300x239.jpg\" alt=\"\" width=\"213\" height=\"170\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/01\/28799atg_therapeutics-300x239.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/01\/28799atg_therapeutics.jpg 450w\" sizes=\"(max-width: 213px) 100vw, 213px\" \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-356b9a7 e-con-full e-flex e-con e-child\" data-id=\"356b9a7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a3ea4dc elementor-widget elementor-widget-text-editor\" data-id=\"a3ea4dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><p>\u00a0<\/p><p><img decoding=\"async\" class=\"size-medium wp-image-69285 aligncenter\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-300x104.png\" alt=\"\" width=\"300\" height=\"104\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-300x104.png 300w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-1024x355.png 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-768x266.png 768w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-1536x532.png 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1.png 2007w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b0b87f1 e-flex e-con-boxed e-con e-parent\" data-id=\"b0b87f1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4267daf elementor-widget elementor-widget-text-editor\" data-id=\"4267daf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><p>CPP2023-010927 project funded by:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1cce8d4 e-flex e-con-boxed e-con e-parent\" data-id=\"1cce8d4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e38ee6f elementor-widget elementor-widget-image\" data-id=\"e38ee6f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"155\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-3-1024x198.jpg\" class=\"attachment-large size-large wp-image-75600\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-3-1024x198.jpg 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-3-300x58.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-3-768x149.jpg 768w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-3-1536x298.jpg 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-3-2048x397.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" 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Beyond basic research, the focus is on advancing its pharmacological and preclinical development, aiming for [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":76149,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[149,142],"tags":[112],"class_list":["post-76161","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aei-en","category-health-technologies-en","tag-projects"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>META-THRIVE - Leitat Technological Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"META-THRIVE - Leitat Technological Center\" \/>\n<meta property=\"og:description\" content=\"Development of a new targeted therapy for the treatment of metabolically adapted tumors Abstract: The main goal of this project is to develop a thymidine phosphorylase (TP) inhibitor as a completely novel oral, intracellular, and targeted therapy for cancer treatment. 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