{"id":81867,"date":"2026-03-06T07:55:36","date_gmt":"2026-03-06T07:55:36","guid":{"rendered":"https:\/\/leitat.org\/blog\/leitat-reforca-les-seves-capacitats-en-dispositius-medics-personalitzats-amb-els-avencos-assolits-a-la-xarxa-dim%ce%b5d\/"},"modified":"2026-03-06T08:54:08","modified_gmt":"2026-03-06T08:54:08","slug":"leitat-strengthen-its-capabilities-in-personalized-medical-devices-with-advances-achieved-in-the-red-dim%ce%b5d","status":"publish","type":"post","link":"https:\/\/leitat.org\/en\/blog\/leitat-strengthen-its-capabilities-in-personalized-medical-devices-with-advances-achieved-in-the-red-dim%ce%b5d\/","title":{"rendered":"Leitat strengthens its capabilities in personalized medical devices with advances achieved in the Red DiM\u03b5D"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"81867\" class=\"elementor elementor-81867 elementor-81835\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6e8671f e-flex e-con-boxed e-con e-parent\" data-id=\"6e8671f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c764cf0 elementor-widget elementor-widget-text-editor\" data-id=\"c764cf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><p><strong>The DiM\u03b5D project has enabled progress in technologies for surgical implants adapted to each patient through the research of new biocompatible materials and improvements in implant adaptation to specific injuries.<\/strong><\/p><\/li><li><p><strong>These results strengthen Leitat\u2019s capabilities in additive manufacturing, biofabrication and validation of advanced medical solutions, contributing to the advancement of personalized medicine.<\/strong><\/p><\/li><li><p><strong>The Red DiM\u03b5D, funded by CDTI through the Red de Excelencia Cervera and coordinated by IDONIAL, includes the participation of the technology centres Leitat, AIN and Vicomtech.<\/strong><\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-12fe181 e-flex e-con-boxed e-con e-parent\" data-id=\"12fe181\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9a6ef6f elementor-widget elementor-widget-text-editor\" data-id=\"9a6ef6f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Leitat has achieved relevant advances in the development and validation of personalized invasive medical devices within the framework of the Red de Excelencia Cervera DiM\u03b5D. Thanks to this project, Leitat has developed new technological solutions ranging from the design of advanced implants to their preclinical validation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-015b1ee e-flex e-con-boxed e-con e-parent\" data-id=\"015b1ee\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ab888f4 elementor-widget elementor-widget-image\" data-id=\"ab888f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-2-1024x768.jpg\" class=\"attachment-large size-large wp-image-81841\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-2-1024x768.jpg 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-2-300x225.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-2-768x576.jpg 768w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-2-1536x1152.jpg 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-2.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4121869 e-flex e-con-boxed e-con e-parent\" data-id=\"4121869\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e40e3e1 elementor-widget elementor-widget-text-editor\" data-id=\"e40e3e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>These are the main results achieved:<\/p><ul><li><p><strong>New implants with improved materials and greater biological integration<\/strong>: Leitat has developed and validated <strong>osteochondral implants using metal additive manufacturing<\/strong>.<br \/>One of the key advances was the <strong>parameterization of new biocompatible alloys<\/strong>, optimizing their mechanical properties so they better adapt to the real conditions of bone and cartilage.<br \/>Additionally, the incorporation of <strong>advanced post-processing processes and functional coatings<\/strong> has improved implant integration into tissue and enhanced cellular response. These developments were validated through cytotoxicity tests in accordance with <strong>ISO 10993<\/strong> standards, ensuring their biological safety.<\/p><\/li><li><p><strong>More precise surgical guides adapted to minimally invasive surgery<\/strong>: Leitat has designed and <strong>manufactured personalized surgical guides and other invasive devices<\/strong> oriented to minimally invasive procedures.<br \/>The work included optimization of sterilization processes and biological validation, ensuring compliance with regulatory requirements in hospital environments.<\/p><\/li><li><p><strong>New inkjet technology to print devices with biocompatible hydrogels<\/strong>: The project enabled the development of a specific inkjet printing system for manufacturing medical devices with biocompatible hydrogels.<br \/>This technology facilitates the use of soft materials that better mimic the behavior of human tissues, opening new possibilities in regenerative medicine and in the development of more realistic biological models for research.<\/p><\/li><li><p><strong>Advanced bioprinting and models that simulate real tissues<\/strong>:<br \/>Leitat has advanced in bioprinting through systems that combine <strong>light-based printing and drop-on-demand<\/strong> technology to generate complex tissue models.<br \/>The developed solutions incorporate <strong>perfusion systems<\/strong> that allow printed tissues to be nourished to promote their maturation, as well as architectures designed to promote vascularization.<br \/>These models make it possible to recreate physiological microenvironments, study metabolic and vascular functions and accelerate the development of new therapies in biomedical research and regenerative medicine, particularly in complex tissues such as liver and arteries.<\/p><\/li><li><p><strong>Cell-laden implants and improved regeneration results<\/strong>:<br \/>In the field of preclinical validation, Leitat has worked on surgical planning and in vivo validation of <strong>personalized 3D bioimplants<\/strong>.<br \/>Results showed a significant improvement in tissue regeneration when implants incorporated living cells compared to those that did not. In simple terms, cell-loaded implants helped the body regenerate damaged tissue more effectively.<\/p><\/li><\/ul><p>These developments confirm the potential of <strong>advanced manufacturing and biofabrication<\/strong> to create medical solutions adapted to the specific characteristics of each patient, contributing to improved surgical precision, implant functionality and patients\u2019 quality of life.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-48cf98a e-flex e-con-boxed e-con e-parent\" data-id=\"48cf98a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-9b6b9c5 e-con-full e-flex e-con e-child\" data-id=\"9b6b9c5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a6b9b58 elementor-widget elementor-widget-image\" data-id=\"a6b9b58\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"567\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-3.png\" class=\"attachment-large size-large wp-image-81844\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-3.png 959w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-3-300x213.png 300w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-3-768x545.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-13d1628 e-con-full e-flex e-con e-child\" data-id=\"13d1628\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a3bdf2c elementor-widget elementor-widget-image\" data-id=\"a3bdf2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"225\" height=\"300\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-4-225x300.jpg\" class=\"attachment-medium size-medium wp-image-81847\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-4-225x300.jpg 225w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-4.jpg 473w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7111404 e-con-full e-flex e-con e-child\" data-id=\"7111404\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-472641f elementor-widget elementor-widget-image\" data-id=\"472641f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"686\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-5-1024x878.jpg\" class=\"attachment-large size-large wp-image-81850\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-5-1024x878.jpg 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-5-300x257.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-5-768x658.jpg 768w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-5-1536x1316.jpg 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-5-2048x1755.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6547a58 e-flex e-con-boxed e-con e-parent\" data-id=\"6547a58\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f260946 elementor-widget elementor-widget-text-editor\" data-id=\"f260946\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Certification and strengthening of technological capabilities<\/strong><\/p><p>One of the most relevant milestones achieved by Leitat within the framework of the project has been the obtaining of the <strong>UNE-EN ISO 13485:2018 certification for the design of four types of medical devices<\/strong>.<\/p><p>This certification consolidates the entity as a <strong>key agent<\/strong> in healthcare innovation in the country, guaranteeing the highest quality standard while accompanying companies throughout the entire process, from <strong>research<\/strong> to the <strong>prototyping of medical devices<\/strong>.<\/p><p>In addition, the project has contributed to consolidating <strong>infrastructures, methodologies and key knowledge<\/strong> that will allow Leitat to continue promoting the development of personalized medical devices in collaboration with companies, hospitals and other actors of the healthcare ecosystem.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3758da8 e-flex e-con-boxed e-con e-parent\" data-id=\"3758da8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3fb48e elementor-widget elementor-widget-image\" data-id=\"f3fb48e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"466\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-6-1024x597.jpg\" class=\"attachment-large size-large wp-image-81853\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-6-1024x597.jpg 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-6-300x175.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-6-768x448.jpg 768w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-6.jpg 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-671aff4 e-flex e-con-boxed e-con e-parent\" data-id=\"671aff4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f6b5107 elementor-widget elementor-widget-text-editor\" data-id=\"f6b5107\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Training, transfer and talent generation<\/strong><\/p><p>In parallel to the technological developments, Leitat has participated in <strong>activities of specialized training, knowledge transfer and advisory services to companies<\/strong>, contributing to strengthening the MedTech ecosystem and facilitating the adoption of advanced technologies in the healthcare field.<\/p><p>Likewise, the Red DiM\u03b5D has enabled Leitat the training of third-degree students for the development of two new doctoral theses. These actions have made it possible to reinforce the positioning of <strong>Leitat as a reference technological partner in the development of personalized medical devices<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ccfcfae e-flex e-con-boxed e-con e-parent\" data-id=\"ccfcfae\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d928d0f elementor-widget elementor-widget-image\" data-id=\"d928d0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"532\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-7-1024x681.jpg\" class=\"attachment-large size-large wp-image-81856\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-7-1024x681.jpg 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-7-300x199.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-7-768x510.jpg 768w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-7-1536x1021.jpg 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-7.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-55505b0 e-flex e-con-boxed e-con e-parent\" data-id=\"55505b0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-113657f elementor-widget elementor-widget-text-editor\" data-id=\"113657f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>M\u00e9s informaci\u00f3 disponible a: <a href=\"https:\/\/dimed.es\/\">https:\/\/dimed.es\/<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cf172db e-flex e-con-boxed e-con e-parent\" data-id=\"cf172db\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-74b71ce elementor-widget elementor-widget-image\" data-id=\"74b71ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"59\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-8-1024x75.jpg\" class=\"attachment-large size-large wp-image-81859\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-8-1024x75.jpg 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-8-300x22.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-8-768x56.jpg 768w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-8-1536x113.jpg 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/03\/Dimed-8-2048x151.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The DiM\u03b5D project has enabled progress in technologies for surgical implants adapted to each patient through the research of new biocompatible materials and improvements in implant adaptation to specific injuries. These results strengthen Leitat\u2019s capabilities in additive manufacturing, biofabrication and validation of advanced medical solutions, contributing to the advancement of personalized medicine. The Red DiM\u03b5D, [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":81837,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[126,146,142,100,99],"tags":[208],"class_list":["post-81867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-additive-manufacturing-3d-printing-en","category-cdti-en","category-health-technologies-en","category-latest-news","category-press-releases","tag-blog-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Leitat strengthens its capabilities in personalized medical devices with advances achieved in the Red DiM\u03b5D - Leitat Technological Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Leitat strengthens its capabilities in personalized medical devices with advances achieved in the Red DiM\u03b5D - Leitat Technological Center\" \/>\n<meta property=\"og:description\" content=\"The DiM\u03b5D project has enabled progress in technologies for surgical implants adapted to each patient through the research of new biocompatible materials and improvements in implant adaptation to specific injuries. These results strengthen Leitat\u2019s capabilities in additive manufacturing, biofabrication and validation of advanced medical solutions, contributing to the advancement of personalized medicine. 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