{"id":85887,"date":"2026-06-17T09:54:13","date_gmt":"2026-06-17T09:54:13","guid":{"rendered":"https:\/\/leitat.org\/?p=85887"},"modified":"2026-06-17T11:12:23","modified_gmt":"2026-06-17T11:12:23","slug":"adc-crc","status":"publish","type":"post","link":"https:\/\/leitat.org\/en\/blog\/adc-crc\/","title":{"rendered":"ADC-CRC"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"85887\" class=\"elementor elementor-85887 elementor-85791\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-415eb99 e-flex e-con-boxed e-con e-parent\" data-id=\"415eb99\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5269045 elementor-widget elementor-widget-text-editor\" data-id=\"5269045\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Leitat, Ona Therapeutics and IRB Barcelona Collaborate to Develop a New Therapy for Colorectal Cancer<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c7f191c elementor-widget elementor-widget-text-editor\" data-id=\"c7f191c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><strong>The objective of the ADC-CRC project is to develop a novel biologic that exploits the uptake of essential amino acids to specifically deliver cytotoxic payloads for the treatment of colorectal cancer.<\/strong><\/li><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><strong>The project has received \u20ac2.2 million in funding from the 2023 Public-Private Collaboration Projects call of the Spanish Ministry of Science, Innovation and Universities.<\/strong><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1ddaa21 e-flex e-con-boxed e-con e-parent\" data-id=\"1ddaa21\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c5464ee elementor-widget elementor-widget-text-editor\" data-id=\"c5464ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Abstract:<\/strong><\/p><p class=\"isSelectedEnd\">The ADC-CRC project, funded under the 2023 Public-Private Collaboration Projects call, aims to revolutionize the treatment of metastatic colorectal cancer, particularly for patients who do not respond to current immunotherapies. The approach is based on the development of a novel Antibody-Drug Conjugate (ADC) targeting an amino acid transporter protein, a target that is highly expressed in colorectal tumors, especially those harboring KRAS mutations and exhibiting resistance to chemotherapy.<\/p><p class=\"isSelectedEnd\">The consortium brings together the expertise of the Amino Acid Transporters and Disease Research Group led by Dr. Manuel Palac\u00edn at IRB Barcelona\u2014who has spent more than 30 years investigating this class of transporters\u2014as well as Leitat\u2019s antibody discovery and validation technology and Ona Therapeutics\u2019 know-how in the design and development of biological therapies. Ona Therapeutics is a pioneering biopharmaceutical company focused on the development of first-in-class antibody-drug conjugates (ADCs) to address treatment-resistant cancers.<\/p><p>The project will develop and select the most promising antibodies using proprietary platforms and patient-derived libraries. In addition, patient-derived xenograft (PDX) models and patient-derived organoids will be used to evaluate the efficacy of the treatment. The combination of scientific expertise, advanced technological platforms and preclinical models positions this project as a high-impact initiative aimed at improving the prognosis of patients with advanced colorectal cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1aa4b07 e-flex e-con-boxed e-con e-parent\" data-id=\"1aa4b07\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-76e5b33 elementor-widget elementor-widget-text-editor\" data-id=\"76e5b33\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Leitat&#8217;s role in the project:<\/strong><\/p><p>Leitat will participate as a beneficiary partner in the <strong>ADC-CRC<\/strong>\u00a0project.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-564a153 e-flex e-con-boxed e-con e-parent\" data-id=\"564a153\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5f7b0af e-con-full e-flex e-con e-child\" data-id=\"5f7b0af\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6186b8c elementor-widget elementor-widget-text-editor\" data-id=\"6186b8c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Project Budget: <\/strong><span class=\"TextRun SCXW92909067 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW92909067 BCX8\">2.242.953,60<\/span><span class=\"NormalTextRun SCXW92909067 BCX8\">\u20ac<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ce4f276 e-con-full e-flex e-con e-child\" data-id=\"ce4f276\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2be496c elementor-widget elementor-widget-text-editor\" data-id=\"2be496c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Leitat Budget:<\/strong>\u00a0 \u00a0 <span class=\"TextRun SCXW140426297 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW140426297 BCX8\">550.088,75<\/span><span class=\"NormalTextRun SCXW140426297 BCX8\">\u20ac<\/span><\/span><span class=\"EOP SCXW140426297 BCX8\" data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3b011d9 e-con-full e-flex e-con e-child\" data-id=\"3b011d9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-86bbba5 elementor-widget elementor-widget-text-editor\" data-id=\"86bbba5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Coordinator: <\/strong><span class=\"TextRun SCXW228060796 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW228060796 BCX8\">ONA THERAPEUTICS SL<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0d4254c e-flex e-con-boxed e-con e-parent\" data-id=\"0d4254c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-15594c9 elementor-widget elementor-widget-text-editor\" data-id=\"15594c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Partners:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5025abd e-flex e-con-boxed e-con e-parent\" data-id=\"5025abd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9aa1c73 elementor-widget elementor-widget-image\" data-id=\"9aa1c73\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"466\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/06\/ADC-LAT1-1-1024x597.png\" class=\"attachment-large size-large wp-image-85875\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/06\/ADC-LAT1-1-1024x597.png 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/06\/ADC-LAT1-1-300x175.png 300w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/06\/ADC-LAT1-1-768x448.png 768w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/06\/ADC-LAT1-1.png 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b9a4c92 e-flex e-con-boxed e-con e-parent\" data-id=\"b9a4c92\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-40ded9c elementor-widget elementor-widget-text-editor\" data-id=\"40ded9c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Project CPP2023-010554 funded by:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-60b3a06 e-flex e-con-boxed e-con e-parent\" data-id=\"60b3a06\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cbd0bb7 elementor-widget elementor-widget-image\" data-id=\"cbd0bb7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"366\" height=\"79\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/06\/Imagen1.png\" class=\"attachment-large size-large wp-image-85878\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2026\/06\/Imagen1.png 366w, https:\/\/leitat.org\/wp-content\/uploads\/2026\/06\/Imagen1-300x65.png 300w\" sizes=\"(max-width: 366px) 100vw, 366px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Leitat, Ona Therapeutics and IRB Barcelona Collaborate to Develop a New Therapy for Colorectal Cancer The objective of the ADC-CRC project is to develop a novel biologic that exploits the uptake of essential amino acids to specifically deliver cytotoxic payloads for the treatment of colorectal cancer. The project has received \u20ac2.2 million in funding from [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":85920,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[149,142],"tags":[112],"class_list":["post-85887","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aei-en","category-health-technologies-en","tag-projects"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ADC-CRC - Leitat Technological Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/leitat.org\/en\/blog\/adc-crc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ADC-CRC - Leitat Technological Center\" \/>\n<meta property=\"og:description\" content=\"Leitat, Ona Therapeutics and IRB Barcelona Collaborate to Develop a New Therapy for Colorectal Cancer The objective of the ADC-CRC project is to develop a novel biologic that exploits the uptake of essential amino acids to specifically deliver cytotoxic payloads for the treatment of colorectal cancer. 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