{"id":17122,"date":"2020-02-04T12:44:00","date_gmt":"2020-02-04T11:44:00","guid":{"rendered":"https:\/\/projects.leitat.org\/?p=17122"},"modified":"2025-02-05T20:24:08","modified_gmt":"2025-02-05T20:24:08","slug":"novel-regeneration-techniques-for-large-bone-defects-launch-of-eu-research-project-sbr","status":"publish","type":"post","link":"https:\/\/leitat.org\/es\/blog\/novel-regeneration-techniques-for-large-bone-defects-launch-of-eu-research-project-sbr\/","title":{"rendered":"Novel Regeneration Techniques for Large Bone Defects: Launch of EU Research Project SBR"},"content":{"rendered":"\r\n<p>The ten academic and industrial partners collaborating in the new EU research project SBR (Smart Bone Regeneration) aim to improve treatment options for patients with large bone defects. The targeted resorbable bone implant will be based on 3D-printed polymers and include advanced technologies for controlled delivery of active molecules to accelerate bone regeneration. Moreover, the included new sensor technologies will allow post-operative monitoring without regular X-ray examinations. Running for a period of four years, the project will receive EUR 6.4 million funding from the European Union\u00e2\u20ac\u2122s Horizon 2020 Framework Programme.<\/p>\r\n\r\n\r\n\r\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"192\" class=\"wp-image-17169\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_costs-increase-1024x192.png\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_costs-increase-1024x192.png 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_costs-increase-300x56.png 300w, https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_costs-increase-768x144.png 768w, https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_costs-increase-1536x287.png 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_costs-increase-2048x383.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\r\n\r\n\r\n\r\n<p>Demographic change and age-linked conditions such as osteoporosis and related fragility fractures pose a significant burden on European healthcare systems. The annual healthcare costs associated with fractures and impaired healing are expected to increase by 23% by the year 2030 (according to the International Osteoporosis Foundation). In order to achieve permanent and well-integrated repairs and significantly improve the patients\u00e2\u20ac\u2122 quality of life, bone grafting techniques are of growing importance in surgical practice.<\/p>\r\n\r\n\r\n\r\n<p>Currently available methods are either using bone originating from the patient (autograft) or donated \/ synthetic bone (allograft). While autografts offer ideal compatibility, they are often not suitable for large bone defects, and allografts suffer from potential rejection by the patient\u00e2\u20ac\u2122s immune system.<\/p>\r\n\r\n\r\n\r\n<p>The interdisciplinary research consortium SBR has now set out to improve state-of-the-art interventions by combining a smart implant with innovative tissue-engineering methods, i.e. in-vitro programming of stem cells and bioactive agents. The solution will contain 3D-printed polymer parts enriched with electrospun fibers that can be customised according to the individual patient\u00e2\u20ac\u2122s physiology, pathology and gender. The framework design will ensure easy placement and include adjustable sensors for post-operative monitoring of e.g. pressure, pH value and temperature. The smart implant will thus be able to provide vital information of implant performance in terms of bone growth and infection\/inflammation.<\/p>\r\n\r\n\r\n\r\n<p>\u00e2\u20ac\u0153Our approach will also be minimally invasive in terms of clinical routines and workflows\u00e2\u20ac\u009d, says Professor Sophia Antimisiaris from the University of Patras, Greece, who coordinates the project together with her colleague Professor Elias Panagiotopoulos. \u00e2\u20ac\u0153As the rigid frame simply clips into place around the bone defect, the system is designed to complement existing practices rather than replacing them. We will also prioritise training opportunities and cooperate closely with the practitioners\u00e2\u20ac\u2122 community to ensure that the novel solution reaches the clinic.\u00e2\u20ac\u009d<\/p>\r\n\r\n\r\n\r\n<p>Within the project lifetime of four years, the in-vivo proof of concept of the SBR solution will be tested in preclinical studies. In the long term, the innovation has the potential to be used in isolation during fracture fixation and become a platform technology for bone conditions at different anatomical sites, including the jaw, spine and pelvis.<\/p>\r\n\r\n\r\n\r\n<p>The SBR consortium comprises ten European partners from France, Germany, Greece, Spain, Switzerland and the UK. On 5-6 February 2020, they come together for the official project kick-off in Patras, Greece.<\/p>\r\n\r\n\r\n\r\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"366\" class=\"wp-image-17170\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_icons_redline-1024x366.png\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_icons_redline-1024x366.png 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_icons_redline-300x107.png 300w, https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_icons_redline-768x274.png 768w, https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_icons_redline-1536x549.png 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2020\/02\/SBR_icons_redline-2048x732.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\r\n\r\n\r\n\r\n<div class=\"wp-block-image\">\r\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" class=\"wp-image-7263\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2016\/03\/flag_yellow_low1.jpg\" alt=\"\" width=\"75\" height=\"50\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2016\/03\/flag_yellow_low1.jpg 600w, https:\/\/leitat.org\/wp-content\/uploads\/2016\/03\/flag_yellow_low1-300x201.jpg 300w\" sizes=\"(max-width: 75px) 100vw, 75px\" \/><\/figure>\r\n<\/div>\r\n\r\n\r\n\r\n<p>This project has received funding from the European Union\u00e2\u20ac\u2122s Horizon 2020 research and innovation programme under grant agreement No 874896.<\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>The ten academic and industrial partners collaborating in the new EU research project SBR (Smart Bone Regeneration) aim to improve treatment options for patients with large bone defects. The targeted resorbable bone implant will be based on 3D-printed polymers and include advanced technologies for controlled delivery of active molecules to accelerate bone regeneration. Moreover, the [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":17216,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[18,14],"tags":[25],"class_list":["post-17122","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-additive-manufacturing-3d-printing","category-health-technologies","tag-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Novel Regeneration Techniques for Large Bone Defects: Launch of EU Research Project SBR - Leitat Technological Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novel Regeneration Techniques for Large Bone Defects: Launch of EU Research Project SBR - Leitat Technological Center\" \/>\n<meta property=\"og:description\" content=\"The ten academic and industrial partners collaborating in the new EU research project SBR (Smart Bone Regeneration) aim to improve treatment options for patients with large bone defects. The targeted resorbable bone implant will be based on 3D-printed polymers and include advanced technologies for controlled delivery of active molecules to accelerate bone regeneration. 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