{"id":19944,"date":"2023-04-11T12:37:00","date_gmt":"2023-04-11T10:37:00","guid":{"rendered":"https:\/\/projects.leitat.org\/?p=19944"},"modified":"2025-02-24T20:38:07","modified_gmt":"2025-02-24T20:38:07","slug":"lkbl208","status":"publish","type":"post","link":"https:\/\/leitat.org\/es\/blog\/lkbl208\/","title":{"rendered":"LKBL208 project"},"content":{"rendered":"\t\t
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LKBL208<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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LKBL208<\/p>

Tratamiento dirigido del c\u00e1ncer de mama triple negativo con un nuevo antagonista oral del receptor de serotonina 1B<\/p>

ABSTRATCT <\/p>

El c\u00e1ncer de mama es la neoplasia m\u00e1s frecuente en mujeres y constituye la patolog\u00eda m\u00e1s mortal femenina a nivel mundial. Este tipo de c\u00e1ncer afecta a m\u00e1s de 2,2 millones de personas cada a\u00f1o. De estos, aproximadamente el 15-20% pertenecen al subtipo triple negativo (TNBC).<\/p>

El tratamiento del TNBC se sustenta en la combinaci\u00f3n de cirug\u00eda y quimioterapia o radioterapia. Los tratamientos alternativos no han supuesto mejoras considerables en el pron\u00f3stico de los pacientes.<\/p>

La presente propuesta se centra en explorar la viabilidad de una soluci\u00f3n novedosa de un producto oral compatible con administraci\u00f3n cr\u00f3nica, sin\u00e9rgico con quimioterapia de amplio espectro, con acci\u00f3n directa sobre la c\u00e9lula cancerosa pero tambi\u00e9n sobre las c\u00e9lulas madre y sobre el nicho osteal en el que podr\u00eda prevenir el anidamiento de las met\u00e1stasis, para el tratamiento del TNBC.<\/p>

El consorcio tiene como objetivo explorar la viabilidad de tratar el c\u00e1ncer de mama triple negativo actuando sobre una nueva diana terap\u00e9utica descrita para tumores hematol\u00f3gicos, el receptor de serotonina HTR1B. Para ello se explorar\u00e1 la eficacia cl\u00ednica de una nueva mol\u00e9cula obtenida por la empresa Leukos Bioteh SL<\/p>

Adem\u00e1s, los objetivos espec\u00edficos del proyecto son: 1) la determinaci\u00f3n de la implicaci\u00f3n del HTR1B en la patogenia del c\u00e1ncer de mama triple negativo; 2) estudiar el potencial antineopl\u00e1sico del antagonismo HTR1B en el c\u00e1ncer de mama metast\u00e1sico; 3) optimizar la determinaci\u00f3n de la expresi\u00f3n de HTR1B en muestra primarias de c\u00e1ncer de mama y la realizaci\u00f3n del ensayo cl\u00ednico.<\/p>


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Project Budget: 1.340.369,16 \u20ac                 <\/p>

LEITAT Budget: 148.674 \u20ac                           <\/p>

Financial Framework: Proyectos en colaboraci\u00f3n p\u00fablico-privada 2021                          <\/p>

Start Date: 01\/03\/2022<\/p>

End Date: 28\/02\/2025<\/p>


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Coordinator:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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<\/span><\/p>

Proyecto CPP2021-008715 financiado por:<\/o:p><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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LKBL208 LKBL208 Tratamiento dirigido del c\u00e1ncer de mama triple negativo con un nuevo antagonista oral del receptor de serotonina 1B ABSTRATCT El c\u00e1ncer de mama es la neoplasia m\u00e1s frecuente en mujeres y constituye la patolog\u00eda m\u00e1s mortal femenina a nivel mundial. Este tipo de c\u00e1ncer afecta a m\u00e1s de 2,2 millones de personas cada […]<\/p>\n","protected":false},"author":4,"featured_media":25343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[13,14],"tags":[15],"class_list":["post-19944","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aei","category-health-technologies","tag-proyectos"],"yoast_head":"\nLKBL208 project - Leitat Technological Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LKBL208 project - Leitat Technological Center\" \/>\n<meta property=\"og:description\" content=\"LKBL208 LKBL208 Tratamiento dirigido del c\u00e1ncer de mama triple negativo con un nuevo antagonista oral del receptor de serotonina 1B ABSTRATCT El c\u00e1ncer de mama es la neoplasia m\u00e1s frecuente en mujeres y constituye la patolog\u00eda m\u00e1s mortal femenina a nivel mundial. 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