{"id":75176,"date":"2024-07-31T10:42:54","date_gmt":"2024-07-31T10:42:54","guid":{"rendered":"https:\/\/leitat.org\/blog\/nextom\/"},"modified":"2025-12-18T08:02:46","modified_gmt":"2025-12-18T08:02:46","slug":"nextom","status":"publish","type":"post","link":"https:\/\/leitat.org\/es\/blog\/nextom\/","title":{"rendered":"NEXTOM"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"75176\" class=\"elementor elementor-75176 elementor-75161\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2cb2b84 e-flex e-con-boxed e-con e-parent\" data-id=\"2cb2b84\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-653a83e elementor-widget elementor-widget-text-editor\" data-id=\"653a83e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Desarrollo de ADCs (Antibody-Drug Conjugates) de Nueva Generaci\u00f3n para el Tratamiento de Tumores Invasivos<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f56ade0 e-flex e-con-boxed e-con e-parent\" data-id=\"f56ade0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7cb19e5 elementor-widget elementor-widget-text-editor\" data-id=\"7cb19e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Abstract:<\/strong><\/p><p>El proyecto <strong>NEXTOM<\/strong> tiene como objetivo <strong>desarrollar conjugados anticuerpo-f\u00e1rmaco (ADCs) innovadores dirigidos a dianas del microentorno tumoral (como FAP, Endoglina y Endo180), para tratar tumores s\u00f3lidos invasivos con mayor eficacia y menor toxicidad<\/strong>.<\/p><p>La iniciativa incluye la selecci\u00f3n de candidatos terap\u00e9uticos, su validaci\u00f3n en modelos precl\u00ednicos avanzados, incluidos animales con sistema inmune humanizado, y el estudio de su estabilidad, farmacocin\u00e9tica y perfil toxicol\u00f3gico. Tambi\u00e9n se desarrollar\u00e1 el proceso de fabricaci\u00f3n y un lote piloto que permita avanzar hacia la fase cl\u00ednica.<\/p><p><strong>Rol de Leitat en el proyecto:<\/strong><\/p><p>El proyecto est\u00e1 liderado por <strong>Oncomatryx<\/strong>, con la colaboraci\u00f3n de <strong>Leitat<\/strong>, que aporta su <strong>experiencia en modelos precl\u00ednicos, ADME y bioan\u00e1lisis<\/strong>.<\/p><p>NEXTOM busca ampliar el arsenal terap\u00e9utico disponible en oncolog\u00eda, reforzando la innovaci\u00f3n en terapias dirigidas al estroma tumoral favoreciendo la transici\u00f3n hacia la medicina personalizada.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5423518 e-flex e-con-boxed e-con e-parent\" data-id=\"5423518\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7d48f8a e-con-full e-flex e-con e-child\" data-id=\"7d48f8a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-77e7b5e elementor-widget elementor-widget-text-editor\" data-id=\"77e7b5e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Presupuesto del proyecto<\/strong>: 2.437.053 \u20ac<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9ffc4f6 e-con-full e-flex e-con e-child\" data-id=\"9ffc4f6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-597e9dc elementor-widget elementor-widget-text-editor\" data-id=\"597e9dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Marco financiero<\/strong>: Proyectos de colaboraci\u00f3n p\u00fablico-privada 2023<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c888705 e-con-full e-flex e-con e-child\" data-id=\"c888705\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-887d019 elementor-widget elementor-widget-text-editor\" data-id=\"887d019\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fecha de inicio<\/strong>: 01\/07\/2024<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2644b2e e-con-full e-flex e-con e-child\" data-id=\"2644b2e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3575974 elementor-widget elementor-widget-text-editor\" data-id=\"3575974\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Presupuesto de Leitat<\/strong>: 852.499 \u20ac<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-484fc54 e-con-full e-flex e-con e-child\" data-id=\"484fc54\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-08575d2 elementor-widget elementor-widget-text-editor\" data-id=\"08575d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>N\u00famero de contrato<\/strong>: CPP2023-010413<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1fd440e e-con-full e-flex e-con e-child\" data-id=\"1fd440e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2e13c5a elementor-widget elementor-widget-text-editor\" data-id=\"2e13c5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"1174\" data-end=\"1392\"><strong>Fecha de finalizaci\u00f3n<\/strong>: 30\/06\/2027<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6040881 e-flex e-con-boxed e-con e-parent\" data-id=\"6040881\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31433c4 elementor-widget elementor-widget-text-editor\" data-id=\"31433c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Partners:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ce7fee e-flex e-con-boxed e-con e-parent\" data-id=\"7ce7fee\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-29e5dec e-con-full e-flex e-con e-child\" data-id=\"29e5dec\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-af740db elementor-widget elementor-widget-image\" data-id=\"af740db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"202\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/OMTX_HD_sinfondo.webp\" class=\"attachment-large size-large wp-image-75168\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/OMTX_HD_sinfondo.webp 993w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/OMTX_HD_sinfondo-300x76.webp 300w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/OMTX_HD_sinfondo-768x194.webp 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1669e88 e-con-full e-flex e-con e-child\" data-id=\"1669e88\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-96901d7 elementor-widget elementor-widget-image\" data-id=\"96901d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"277\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-1024x355.png\" class=\"attachment-large size-large wp-image-69284\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-1024x355.png 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-300x104.png 300w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-768x266.png 768w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1-1536x532.png 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/04\/Leitat_logo_transparente-1.png 2007w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8ef967b e-flex e-con-boxed e-con e-parent\" data-id=\"8ef967b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8d01860 elementor-widget elementor-widget-text-editor\" data-id=\"8d01860\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Proyecto CPP2023-010413 financiado por:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dfe8fa9 e-flex e-con-boxed e-con e-parent\" data-id=\"dfe8fa9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-44a45b6 elementor-widget elementor-widget-image\" data-id=\"44a45b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"155\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-1024x198.jpg\" class=\"attachment-large size-large wp-image-75299\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-1024x198.jpg 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-300x58.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-768x149.jpg 768w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-1536x298.jpg 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2025\/12\/MICIUCofinanciadoAEI_Ivan-Ortiz-Martin-2-2048x397.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Desarrollo de ADCs (Antibody-Drug Conjugates) de Nueva Generaci\u00f3n para el Tratamiento de Tumores Invasivos Abstract: El proyecto NEXTOM tiene como objetivo desarrollar conjugados anticuerpo-f\u00e1rmaco (ADCs) innovadores dirigidos a dianas del microentorno tumoral (como FAP, Endoglina y Endo180), para tratar tumores s\u00f3lidos invasivos con mayor eficacia y menor toxicidad. La iniciativa incluye la selecci\u00f3n de candidatos [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":75164,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[13,14],"tags":[15],"class_list":["post-75176","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aei","category-health-technologies","tag-proyectos"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NEXTOM - Leitat Technological Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NEXTOM - Leitat Technological Center\" \/>\n<meta property=\"og:description\" content=\"Desarrollo de ADCs (Antibody-Drug Conjugates) de Nueva Generaci\u00f3n para el Tratamiento de Tumores Invasivos Abstract: El proyecto NEXTOM tiene como objetivo desarrollar conjugados anticuerpo-f\u00e1rmaco (ADCs) innovadores dirigidos a dianas del microentorno tumoral (como FAP, Endoglina y Endo180), para tratar tumores s\u00f3lidos invasivos con mayor eficacia y menor toxicidad. 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