{"id":8092,"date":"2014-07-31T12:39:39","date_gmt":"2014-07-31T10:39:39","guid":{"rendered":"http:\/\/dev-leitat-projects-blog.pantheonsite.io\/?p=8092"},"modified":"2025-02-24T20:34:06","modified_gmt":"2025-02-24T20:34:06","slug":"neqam","status":"publish","type":"post","link":"https:\/\/leitat.org\/es\/blog\/neqam\/","title":{"rendered":"NEQAM"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"8092\" class=\"elementor elementor-8092\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fwbzixu elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fwbzixu\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-zdzwwjj\" data-id=\"zdzwwjj\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-jmptjwe elementor-widget elementor-widget-heading\" data-id=\"jmptjwe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">NEQAM<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bkvumsc elementor-widget elementor-widget-text-editor\" data-id=\"bkvumsc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5>Development and Application of new Chemometric Strategies for Metabolomic Analysis<\/h5>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-wybnmut elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"wybnmut\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-weyntmw\" data-id=\"weyntmw\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-brdvjtm elementor-widget elementor-widget-text-editor\" data-id=\"brdvjtm\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>ABSTRACT<\/strong><\/p><p style=\"text-align: justify;\">NEQAM project aims at the development, assessment and application of chemometric strategies for the detection and elimination of intra- and inter-batch effects in untarget high resolution liquid chromatography-mass spectrometry (LC-MS).<\/p><p style=\"text-align: justify;\">Batch effect elimination is among the top priorities in LC-MS based metabolomics. It decreases the power to detect biological responses and hinders data interpretation and joint analysis of data acquired in different batches, laboratories, instruments, or analytical platforms, thereby limiting its potential. It is especially critical in human studies where, due to very high inter-subject variability, the number of samples to obtain a given statistical power is higher than that required in in vitro studies or those involving controlled animal models.<\/p><p style=\"text-align: justify;\">An accurate elimination of batch effects in metabolomics will increase the reproducibility and repeatability of the analysis of larger cohorts and, simultaneously, it will enable the use of a higher number of metabolomics features after data clean-up, a simultaneous increase in the precision of multivariate metabolic models and it will facilitate the joint analysis of multi-source data and calibration transfer. In summary, these improvements will have a synergistic effect on the statistical power of metabolomic studies and on their reproducibility and repeatability.<\/p><p style=\"text-align: justify;\">In this project we will continue with the development of batch effect elimination strategies based on the use of quality control (QC) samples and support vector regression (SVR) for the fitting of functions describing changes in the instrument response over the batch. Then, to provide an unbiased evaluation of their applicability they will be thoroughly assessed indifferent scenarios: i) single batch analysis involving a large number of samples; ii) across several batches and LC-MS platforms; and iii) in multi-source metabolomic analysis. This evaluation of the chemometric methods will be carried out during the development of three novel metabolomic applications from different areas of research (bladder cancer, sample quality assessment, nanotoxicology), that will potentially benefit from the application of novel batch effect elimination methods.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-nlguvbd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"nlguvbd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ugsekaw\" data-id=\"ugsekaw\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-nualhrp elementor-widget elementor-widget-text-editor\" data-id=\"nualhrp\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Financial Framework:<\/strong> RETOS COLABORACI\u00d3N<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cxnjpeb elementor-widget elementor-widget-text-editor\" data-id=\"cxnjpeb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contract number: <\/strong>CTQ2016-79561-P<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-mtwlwul\" data-id=\"mtwlwul\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-unyzqor elementor-widget elementor-widget-text-editor\" data-id=\"unyzqor\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Start Date:<\/strong> 30\/12\/2016<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-hdgikbj elementor-widget elementor-widget-text-editor\" data-id=\"hdgikbj\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>End Date:<\/strong> 29\/12\/2019<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-avzqekj elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"avzqekj\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-zhtdudb\" data-id=\"zhtdudb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-qivmrny elementor-widget elementor-widget-text-editor\" data-id=\"qivmrny\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Partners:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-agpyvcl elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"agpyvcl\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-kpnpykg\" data-id=\"kpnpykg\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-mnipuhc elementor-widget elementor-widget-image-gallery\" data-id=\"mnipuhc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-gallery\">\n\t\t\t<div id='gallery-1' class='gallery galleryid-8092 gallery-columns-4 gallery-size-blog-list-post-size'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<img width=\"200\" height=\"76\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2017\/08\/Leitat_ppt-200.png\" class=\"attachment-blog-list-post-size size-blog-list-post-size\" alt=\"\" decoding=\"async\" \/>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-chbhqie elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"chbhqie\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ldwkmja\" data-id=\"ldwkmja\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-zesldfz elementor-widget elementor-widget-text-editor\" data-id=\"zesldfz\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contact Manager:<\/strong> <a href=\"mailto:snieva@leitat.org\">S. Nieva<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-mozrgpk elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"mozrgpk\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-ukovsel\" data-id=\"ukovsel\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ptqiqhx elementor-widget elementor-widget-image\" data-id=\"ptqiqhx\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"155\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-1024x199.jpg\" class=\"attachment-large size-large wp-image-14328\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-1024x199.jpg 1024w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-300x58.jpg 300w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-768x149.jpg 768w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI-1536x298.jpg 1536w, https:\/\/leitat.org\/wp-content\/uploads\/2019\/04\/MCIU_Gob_Web_AEI.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c5827c8 elementor-widget elementor-widget-image\" data-id=\"c5827c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"535\" height=\"142\" src=\"https:\/\/leitat.org\/wp-content\/uploads\/2016\/10\/LOGO_FEDER_es-670x300-1.png\" class=\"attachment-large size-large wp-image-40410\" alt=\"\" srcset=\"https:\/\/leitat.org\/wp-content\/uploads\/2016\/10\/LOGO_FEDER_es-670x300-1.png 535w, https:\/\/leitat.org\/wp-content\/uploads\/2016\/10\/LOGO_FEDER_es-670x300-1-300x80.png 300w\" sizes=\"(max-width: 535px) 100vw, 535px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-urwuknm\" data-id=\"urwuknm\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-zrwnkpt elementor-widget elementor-widget-text-editor\" data-id=\"zrwnkpt\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Financiado por: FEDER\/Ministerio de Ciencia,Innovaci\u00f3n y Universidades \u2013 Agencia Estatal de Investigaci\u00f3n\/_Proyecto CTQ2016-79561-P<\/p><p>Objetivo Tem\u00e1tico del Programa Operativo: Promover el desarrollo tecnol\u00f3gico, la innovaci\u00f3n y una investigaci\u00f3n de calidad.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>NEQAM Development and Application of new Chemometric Strategies for Metabolomic Analysis ABSTRACT NEQAM project aims at the development, assessment and application of chemometric strategies for the detection and elimination of intra- and inter-batch effects in untarget high resolution liquid chromatography-mass spectrometry (LC-MS). Batch effect elimination is among the top priorities in LC-MS based metabolomics. It [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":14456,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[14],"tags":[15],"class_list":["post-8092","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-technologies","tag-proyectos"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NEQAM - Leitat Technological Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NEQAM - Leitat Technological Center\" \/>\n<meta property=\"og:description\" content=\"NEQAM Development and Application of new Chemometric Strategies for Metabolomic Analysis ABSTRACT NEQAM project aims at the development, assessment and application of chemometric strategies for the detection and elimination of intra- and inter-batch effects in untarget high resolution liquid chromatography-mass spectrometry (LC-MS). 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